This site is intended for US healthcare professionals only.

WHAT IS OPTUNE PAX®?

In adult patients with locally advanced pancreatic cancer,

Optune Pax® is an FDA-approved wearable therapeutic device that delivers TTFields noninvasively to the tumor site1,2

What are Tumor Treating Fields (TTFields)?

TTFields are alternating electric fields that target the electrical properties of cancer cells to disrupt cell viability without significantly affecting healthy cells.3-5

What is Optune Pax?

Electric field generator: The portable field generator can be carried by your patient to deliver TTFields as they go about their day.1

Transducer arrays: Sterile, single-use transducer arrays are placed on the abdomen and connect to the field generator to deliver therapy. Arrays should be replaced  2 times per week (every 3–4 days).1,2

Portable power supply, batteries, and charger: A charger keeps portable batteries charged and ready to fit your patient’s schedule. The field generator can be powered via batteries or a wall outlet.1,2

Should be used at least 12 hours per day1

Patients have the flexibility to decide which times of the day work best to use Optune Pax.1

Optune Pax delivers TTFields noninvasively to the tumor site1,2

Learn more about TTFields

AE=adverse event; FDA=US Food and Drug Administration.

 

 

 

References: 1. Optune Pax for Locally Advanced Pancreatic Cancer (LAPC). Physician Instructions for Use. Novocure; 2026. 2. Novocure Data on File 2025. [EF-27 (PANOVA-3) Study protocol.] 3. Vergote I, Macarulla T, Hirsch FR, Hagemann C, Miller DS. Tumor treating fields (TTFields) therapy concomitant with taxanes for cancer treatment. Cancers (Basel). 2023;15(3):636. doi:10.3390/ cancers15030636 4. Karanam NK, Story MD. An overview of potential novel mechanisms of action underlying tumor treating fields-induced cancer cell death and their clinical implications. Int J Radiat Biol. 2021;97(8):1044-1054. doi:10.1080/09553002.2020.1837984 5. Ahmad MA, Al Natour Z, Mustafa F, Rizvi TA. Electrical characterization of normal and cancer cells. IEEE Access. 2018;6:25979-25986. doi:10.1109/access.2018.2830883

 

 

Indication for Use

Optune Pax® is intended for the treatment of adult patients with locally advanced pancreatic cancer, concomitant with gemcitabine and nab-paclitaxel.

Important Safety Information

Contraindications

Do not use Optune Pax in patients with an electrical implant. Use of Optune Pax together with electrical implants has not been tested and may lead to malfunctioning of the implanted device.

Do not use Optune Pax in patients with a known sensitivity to conductive hydrogels. In patients with this sensitivity, skin contact with the gel used with Optune Pax may commonly cause increased redness and itching. In rare cases, it may lead to severe allergic reactions that can cause a drop in blood pressure and difficulty breathing.

Warnings and Precautions

Optune Pax can only be prescribed by a healthcare provider who has completed the required certification training provided by Novocure® (the device manufacturer).

Do not prescribe Optune Pax for patients who are pregnant, who you think might be pregnant, or who are trying to get pregnant. Women who are able to get pregnant must use birth control when using the device. Safety and effectiveness of Optune Pax in these populations have not been established.

The most common (≥10%) adverse events involving Optune Pax concomitant with gemcitabine and nab-paclitaxel were neutropenia, anemia, thrombocytopenia, leukopenia, diarrhea, nausea, vomiting, abdominal pain, constipation, fatigue, peripheral edema, pyrexia, pain, COVID-19, infection, respiratory tract infection, urinary tract infection, pneumonia, hepatic enzyme increased, anorexia, hypokalemia, hypoalbuminemia, hyperglycemia, musculoskeletal pain, peripheral neuropathy, taste disorder, dizziness, sleep disorder, dyspnea, alopecia, skin-related disorders, and hypotension.

Optune Pax device-related skin adverse events (≥5%) include dermatitis, rash, pruritus, maculo-papular rash, erythema, skin irritation, skin reaction, and skin ulcer. Other device-related adverse effects associated with the use of Optune Pax include overheating of the array, leading to pain and/or local skin burns, allergic reaction to the adhesive or gel from the transducer arrays, and local warmth and tingling sensation beneath the arrays.

If the patient has an underlying skin condition on the abdomen, evaluate whether this may prevent or temporarily interfere with Optune Pax treatment.

Please see the Optune Pax Instructions for Use (IFU) for complete information regarding the device’s indication, contraindications, warnings, and precautions.

 

Indication for Use

Optune Pax® is intended for the treatment of adult patients with locally advanced pancreatic cancer, concomitant with gemcitabine and nab-paclitaxel.

Important Safety Information

Contraindications

Do not use Optune Pax in patients with an electrical implant. Use of Optune Pax together with electrical implants has not been tested and may lead to malfunctioning of the implanted device.

Do not use Optune Pax in patients with a known sensitivity to conductive hydrogels. In patients with this sensitivity, skin contact with the gel used with Optune Pax may commonly cause increased redness and itching. In rare cases, it may lead to severe allergic reactions that can cause a drop in blood pressure and difficulty breathing.

Warnings and Precautions

Optune Pax can only be prescribed by a healthcare provider who has completed the required certification training provided by Novocure® (the device manufacturer).

Do not prescribe Optune Pax for patients who are pregnant, who you think might be pregnant, or who are trying to get pregnant. Women who are able to get pregnant must use birth control when using the device. Safety and effectiveness of Optune Pax in these populations have not been established.

The most common (≥10%) adverse events involving Optune Pax concomitant with gemcitabine and nab-paclitaxel were neutropenia, anemia, thrombocytopenia, leukopenia, diarrhea, nausea, vomiting, abdominal pain, constipation, fatigue, peripheral edema, pyrexia, pain, COVID-19, infection, respiratory tract infection, urinary tract infection, pneumonia, hepatic enzyme increased, anorexia, hypokalemia, hypoalbuminemia, hyperglycemia, musculoskeletal pain, peripheral neuropathy, taste disorder, dizziness, sleep disorder, dyspnea, alopecia, skin-related disorders, and hypotension.

Optune Pax device-related skin adverse events (≥5%) include dermatitis, rash, pruritus, maculo-papular rash, erythema, skin irritation, skin reaction, and skin ulcer. Other device-related adverse effects associated with the use of Optune Pax include overheating of the array, leading to pain and/or local skin burns, allergic reaction to the adhesive or gel from the transducer arrays, and local warmth and tingling sensation beneath the arrays.

If the patient has an underlying skin condition on the abdomen, evaluate whether this may prevent or temporarily interfere with Optune Pax treatment.

Please see the Optune Pax Instructions for Use (IFU) for complete information regarding the device’s indication, contraindications, warnings, and precautions.

 

Novocure websites

This website is intended for US healthcare professionals seeking information on Optune Pax.

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US-OPP-00007 v1.0 March 2026